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KMID : 1007420100080020120
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Mood and Emotion
2010 Volume.8 No. 2 p.120 ~ p.125
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The Relationship Between Heart Rate Variability and Symptom Severity in Patients with Major Depressive Disorder
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Jung Chul-Hong
Min Jung-Ah
Seo Ho-Jun
Chae Jeong-Ho
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Abstract
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Objectives：There have been several previous reports about heart rate variability (HRV), which is related to change of autonomic nervous system, was decreased in major depressive disorder (MDD) patients. The present study was based on a hypothesis that severity of symptoms of MDD had effect on decrement of heart rate variability.
Methods：Thirty seven patients who were diagnosed with MDD under DSM-IV criteria were selected for our study.
All patients underwent HAMD and CGI scale to assess the severity of MDD, and drug history was investigated.
Time domain and frequency domain method analyses were used to determine heart rate variability at same time interval,and its relationship with the scores of Hamilton Depression Rating Scale (HAM-D) was compared.
Results：Significant relationship between HAM-D scores and norm low frequency (LF) scale of heart rate variability was observed. Drugs that subjects administered did not have any influence on heart rate variability.
Conclusion：The results of this study revealed that heart rate variability might be affected by improvement or aggravation of severity of depressive symptoms in patients with major depression. However, significance of various factors that affect heart rate variability need further study.
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KEYWORD
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Heart rate variability, Depression, Severity
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